What’s the difference between Restylane Kysse and Regular Restylane?

This was a question I got today as someone on the phone asked the question to one of my staff members. I just heard about the question and thought I’d try to answer the question.

There are different types of Restylane as of 9/28/2020

There is:

Restyane Silk

Restylane Refyne

Restylane Kysse

Restylane Defyne



That’s 6 different Restylane’s. That’s more than the different types of Juvederms that I have at the moment.

Comparison of Restylane Kysse to Regular Restylane-L

Restylane Kysse is a newer filler that came on in 2020. Restylane L has been around as the original filler but without the lidocaine. It was the first filler that I injected back when I started around 2007.

In general I would say that Restylane Kysse is less stiff, and more flexible than Restylane-L, and the syringe that it comes on is different for the injector – just a different design. Restylane Kysse is specifically designed with the lips in mind, and Restylane L is for Nasolabial folds, etc.

There is still so much to fillers and a lot of is how it is used by the injector. These different filler types are tools for injectors to use to help create the goals they have in their mind, and the different fillers exist to help us get to our goals more efficiently.

Some of what we choose to use is based on experience and comfort. I have used Restylane-L under the eyes (tear troughs) for awhile and I’m very comfortable with it there.

I hope that helps answser the question.

Here’s a link to the different types of fillers and which fillers I choose for lips and why. Kind of a: How to choose the right filler for your lip.

In general, I still say, don’t focus too much on the syringe type or brand. Let your injector pick the one that works the best for your goals.

Here’s a rundown of what I think of the different Restylane fillers that I have

Restyane Silk – soft filler, but isn’t very flexible

Restylane Refyne – supersoft filler with a great deal of flexibility

Restylane Kysse – medium firm filler with a good deal of flexibility designed for lips

Restylane Defyne – firmer filler than Kysse with a bit of flexibility

Restylane-L – firm filler with minimal flexibility

Restylane-Lyft – Firmer than Restylane-L filler with minimmal flexibility